環境配慮型の「モノづくり×デジタル」を牽引する研究開発、および関連デジタルソリューションの開発：
a. 環境と経済を両立するライフサイクルエンジニアリング・エコデザイン（ライフサイクルアセスメント(LCA)、ライフサイクルシミュレーション）
b. OT×ITを実現するデジタル製造・解析（多変量解析、ケモメトリクス、プロセスセンシング・アナリティクス、機械学習・AI）
c. 加工プロセス最適化（樹脂成形、金属成形・機械加工、工程設計）
d. 検査・計測（分光、光分析、光学設計、光学シミュレーション）
ライフサイクルエンジニアリング・エコデザイン（ライフサイクルアセスメント(LCA)、ライフサイクルシミュレーション）、デジタル製造・解析（多変量解析、ケモメトリクス、プロセスセンシング・アナリティクス、機械学習・AI）、加工プロセス最適化（樹脂成形、金属成形・機械加工、工程設計）、検査・計測（分光、光分析、光学設計、光学シミュレーション）
Publishing Academic Papers:
T.Kambayashi, T.Noguchi, A.Nojima, S.Kono, S.Taniguchi, Y.Ozaki, "Glucose Monitoring in Cell Culture with Online Ultrasound-Assisted Near-Infrared Spectroscopy", Anal.Chem. 92(4), 2946-2952 (2020)
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b03354
Abstract: Near-infrared (NIR) spectroscopic analysis for suspensions often requires a pretreatment by dilution or filtering of suspended solids to maintain the sensitivity of the measurements. An online ultrasound-assisted spectroscopy (UAS) unit enabling pretreatment-free and noncontact analysis for bioprocessing is proposed and evaluated with a model suspension containing 3-μm-diameter polystyrene latex particles (PSLs) with the density of 5.1 × 108 counts/ml and Chinese hamster ovary (CHO) cell culture whose cell density was 3.2 × 107 cells/ml. The online UAS uses acoustic radiation force generated by ultrasonic standing waves. Suspended matter such as the PSLs and CHO cells can be localized at nodal planes in the suspensions by the acoustic radiation force. Hence, in the case of the online UAS, incoming light can pass through the suspensions more easily than that in the case of a conventional spectroscopy. Its effectiveness was evaluated by the predictive capability of a calibration model for glucose concentrations in the model suspensions and the CHO cell cultures. The calibration models were constructed by use of a partial least-squares regression (PLS-R) in the range of 4900–4200 cm–1 region after the pretreatment of second-order Savitzky-Golay filter. The calibration model built from the NIR spectra acquired with the online UAS could predict the glucose concentration in the CHO cell cultures with a measurement error of 0.6%. It was validated that the glucose concentrations in the flowing model suspension were able to be monitored by the online UAS with a measurement error of 8%. The newly developed online UAS for cell culture monitoring allows us to promote a wider use of NIR spectroscopy. For example, in the applications to the biopharmaceutical and cell-therapy industries, the online UAS enables simpler and easier monitoring of cell cultures because cleaning and sterilization of monitoring tools after cell culturing can be eliminated.
A.Yamaguchi, S.Arai, N.Arai, “Molecular insight into toughening induced by core-shell structure formation in starch-blended bioplastic composites”, Carbohydrate Polymers, 315 (2023).
https://doi.org/10.1016/j.carbpol.2023.120974
Abstract: Binary and ternary blends with poly(lactic acid) (PLA), poly(butylene succinate) (PBS), and thermoplastic starch (TPS) were prepared by a melt process to produce biodegradable biomass plastics with both economical and good mechanical properties. The mechanical and structural properties of each blend were evaluated. Molecular dynamics (MD) simulations were also conducted to examine the mechanisms underlying the mechanical and structural properties. PLA/PBS/TPS blends showed improved mechanical properties compared with PLA/TPS blends. The PLA/PBS/TPS blends with a TPS ratio of 25–40 wt% showed higher impact strength than PLA/PBS blends. Morphology observations showed that in the PLA/PBS/TPS blends, a structure similar to that of core-shell particles with TPS as the embedding phase and PBS as the coating phase was formed, and that the trends in morphology and impact strength changes were consistent. The MD simulations suggested that PBS and TPS tightly adhered to each other in a stable structure at a specific intermolecular distance. From these results, it is clear that PLA/PBS/TPS blends are toughened by the formation of a core-shell structure in which the TPS core and the PBS shell adhered well together and stress concentration and energy absorption occurred in the vicinity of the core-shell structure.
K.Zhang, Y.Bao, M.Cao, S.Taniguchi, M.Watanabe, T.Kambayashi, T.Okamoto, M.Haraguchi, X.Wang, K.Kobayashi, H.Yamada, B.Ren, T.Tachizaki, “Low-Background Tip-Enhanced Raman Spectroscopy Enabled by a Plasmon Thin-Fim Waveguide Probe”, Anal.Chem. 93(21), 7699-7706 (2021)
https://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c00806
Abstract: Tip-enhanced Raman spectroscopy (TERS) is a nano-optical approach to extract spatially resolved chemical information with nanometer precision. However, in the case of direct-illumination TERS, which is often employed in commercial TERS instruments, strong fluorescence or far-field Raman signals from the illuminated areas may be excited as a background. They may overwhelm the near-field TERS signal and dramatically decrease the near-field to far-field signal contrast of TERS spectra. It is still challenging for TERS to study the surface of fluorescent materials or a bulk sample that cannot be placed on an Au/Ag substrate. In this study, we developed an indirect-illumination TERS probe that allows a laser to be focused on a flat interface of a thin-film waveguide located far away from the region generating the TERS signal. Surface plasmon polaritons are generated stably on the waveguide and eventually accumulated at the tip apex, thereby producing a spatially and energetically confined hotspot to ensure stable and high-resolution TERS measurements with a low background. With this thin-film waveguide probe, TERS spectra with obvious contrast from a diamond plate can be acquired. Furthermore, the TERS technique based on this probe exhibits excellent TERS signal stability, a long lifetime, and good spatial resolution. This technique is expected to have commercial potential and enable further popularization and development of TERS technology as a powerful analytical method.
YounJeong Hong, Kenji Nishikawa, Yuki Murasato, Yuki Shimizu, Yoshiteru Katsumura, “Eco-design Towards Sustainable Manufacturing by Environmental Assessment Navigation”, EcoDesign 2023 (2023).
T.Kambayashi, T.Noguchi, A.Nojima, S.Kono, S.Taniguchi, Y.Ozaki, "Glucose Monitoring in Cell Culture with Online Ultrasound-Assisted Near-Infrared Spectroscopy", Anal.Chem. 92(4), 2946-2952 (2020)
Daisuke Yagi, Hidenori Takai, Hiroki Watanabe. “The Algorithm to Discriminate Factors of Defects and Determine the Countermeasures from Process Data and Application to Highly-Functional Film Process,” presented at the 2020 AIChE Annual Meeting.
https://www.aiche.org/academy/videos/conference-presentations/algorithm-discriminate-factors-defects-and-determine-countermeasures-process-data-and-application
河野 一平, 寺前 俊哉, "人と設備に依存しない安定加工を実現する加工デジタルレシピ", 日本機械学会誌, 124(1231), 30-33 (2021)
https://www.jstage.jst.go.jp/article/jsmemag/124/1231/124_30/_article/-char/ja/
K.Zhang, Y.Bao, M.Cao, S.Taniguchi, M.Watanabe, T.Kambayashi, T.Okamoto, M.Haraguchi, X.Wang, K.Kobayashi, H.Yamada, B.Ren, T.Tachizaki, "Low-Background Tip-Enhanced Raman Spectroscopy Enabled by a Plasmon Thin-Film Waveguide Probe", Anal. Chem. 93(21), 7699-7706 (2021).
日立産総研ラボ：循環経済社会の実現に向けた連携研究ラボを設立
https://www.hitachihyoron.com/jp/archive/2020s/2023/01/20/index.html
安全基準の厳しい企業・官公庁向けデータ記憶装置製品に再生プラスチックを採用
https://www.hitachi.co.jp/New/cnews/month/2023/10/1005.html
日立ブランド 家電5製品が「2022年度グッドデザイン賞」を受賞、さらに上位の「グッドデザイン金賞」に日立グループ初の2製品同時選出
https://www.hitachi.co.jp/New/cnews/month/2022/10/1007.html
熟練者と同等の切削加工品質を確保できる切削加工誤差補正技術を開発：
https://www.hitachi.co.jp/New/cnews/month/2018/06/0618.html
"Smart operation recommender system digitalizing OT knowledge to improve productivity"：
https://www.hitachi.com/rd/sc/automation/blog/202106_smart-operation-recommender/index.html
走査型プローブ顕微鏡において、熱ダメージレスで組成や分子構造を計測する技術を開発：
https://www.hitachi.co.jp/New/cnews/month/2017/10/1010c.html
スマート製造を実現する、複雑な部品内面の3D形状計測技術を開発：
https://www.hitachi.co.jp/rd/news/topics/2021/0316.html
